Evidence map›Paper›PMID 42201421›Full record

ArticleHernia : the journal of hernias and abdominal wall surgery2026

Validation of a rat parastomal hernia model for evaluating mesh biocompatibility and repair outcomes.

Xiaoqiang Zhu, Jiajie Liu, Jianfeng Shen, Nan Liu, Mingan Zhong, Rui Tang

Abstract readValidation Study
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In one paragraph

Article in Hernia : the journal of hernias and abdominal wall surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Xiaoqiang ZhuDepartment of Hernia and Abdominal Wall Surgery, Shanghai East Hospital, Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0001-8290-9047
Jiajie LiuDepartment of Hernia and Abdominal Wall Surgery, Shanghai East Hospital, Tongji University, Shanghai, China.
Jianfeng ShenDepartment of Hernia and Abdominal Wall Surgery, Shanghai East Hospital, Tongji University, Shanghai, China.
Nan LiuDepartment of Hernia and Abdominal Wall Surgery, Shanghai East Hospital, Tongji University, Shanghai, China.
Mingan ZhongDepartment of Hernia and Abdominal Wall Surgery, Shanghai East Hospital, Tongji University, Shanghai, China.
Rui TangDepartment of Hernia and Abdominal Wall Surgery, Shanghai East Hospital, Tongji University, Shanghai, China. kevintown@126.com.ORCID http://orcid.org/0000-0002-9761-3393

Funding

Shanghai East Hospital DFRC2017009
6 · The paper itself

Abstract

purposeThe preclinical evaluation of various meshes and surgical techniques for parastomal hernia (PSH) repair is limited due to the lack of a standardized, responsive, and clinically relevant animal model. This study aimed to validate a previously established rat PSH model and evaluate its ability to discriminate the biological and biomechanical properties of diverse meshes.

methodsA total of 24 Sprague-Dawley rats were included in this study. A standardized PSH model was induced by a 3 × 2 cm abdominal wall defect, partial rectus abdominis resection, and functional end-colostomy. Keyhole repair was performed using biological meshes (porcine small intestinal submucosa [SIS] or porcine acellular dermal matrix [ADM]) or synthetic meshes (polyvinylidene fluoride [PVDF] or polypropylene [PP]). The model was validated using metrics such as survival, weight trends, and 8-week host responses, including recurrence/bulging, intestinal adhesion, erosion, inflammation, and angiogenesis.

resultsThe model demonstrated excellent surgical feasibility and tolerance. All groups showed 100% survival and stable weight gain. The model sensitively discriminated mesh-specific outcomes. The SIS group exhibited significantly higher recurrence rates than that of the other groups. The ADM group showed minimal inflammation but moderate adhesion formation. Severe adhesions with histologically confirmed erosion into the stoma intestine were observed in the PVDF and PP groups. Significant differences in inflammation and angiogenesis were observed among the four groups.

conclusionThis rat PSH model provided a validated preclinical platform for evaluating PSH repair strategies and exhibited differential responses among the four meshes in biocompatibility and key repair outcomes.

Indexed as

Hernia, VentralHerniorrhaphyIncisional HerniaSurgical MeshAcellular DermisAnimalsBiocompatible MaterialsColostomyDisease Models, AnimalFluorocarbon PolymersMaleMaterials TestingPolypropylenesPolyvinylsRatsRats, Sprague-DawleyBiocompatible MaterialsFluorocarbon PolymersPolypropylenespolyvinylidene fluoridePolyvinylsBiocompatibilityMesh repairParastomal herniaRat modelValidation

Identifiers

PMID42201421

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