Evidence map›Paper›PMID 42201106›Full record

ArticleEuropean burn journal2026

Japanese Consensus Document on NexoBrid

Hajime Matsumura, Takahiro Ueda, Rei Ogawa, Yasuhiko Kaita, Hiroyuki Sakurai, Kazutaka Soejima, Junichi Sasaki

Abstract read
In one paragraph

Article in European burn journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Japanese Consensus Document on NexoBridEuropean burn journal · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hajime MatsumuraDepartment of Plastic and Reconstructive Surgery, Tokyo Medical University, 6-7-1 Nishishinjyuku, Shinjukuku, Tokyo 160-0023, Japan.ORCID 0000-0001-8788-7684
Takahiro UedaAdvanced Emergency and Critical Care Medical Center, Tottori University Hospital, Yonago, Tottori 683-8504, Japan.ORCID 0000-0002-4214-1325
Rei OgawaDepartment of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Bunkyo-ku, Tokyo 113-8603, Japan.ORCID 0000-0003-3658-555X
Yasuhiko KaitaDepartment of Trauma and Critical Care Medicine, Kyorin University School of Medicine, Mitaka, Tokyo 181-8611, Japan.ORCID 0000-0003-2298-0698
Hiroyuki SakuraiDepartment of Plastic and Reconstructive Surgery, Tokyo Women's Medical University, Shinjuku-ku, Tokyo 161-8666, Japan.
Kazutaka SoejimaDepartment of Plastic and Reconstructive Surgery, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan.
Junichi SasakiDepartment of Emergency and Critical Care Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.ORCID 0000-0002-5190-8524

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNexoBrid

methodsA questionnaire-based survey was conducted using the Delphi method to achieve expert consensus. Consensus was defined as agreement by at least 80% of committee members for each statement. A total of 27 statements were evaluated over two rounds.

resultsConsensus was achieved for 20 of 27 statements (74.1%) in the first round and for 21 of 27 statements (77.8%) in the second round. The finalised statements were organised into seven categories according to their attributes: indications, pain management, application timing, application technique, post-application wound care, skin grafting, and scarring/aesthetic outcomes.

conclusionsThis consensus document integrates the opinions of plastic surgeons and emergency physicians in Japan, while also incorporating relevant international perspectives, to provide practical guidance on the use of NXB for burn treatment. It is intended to improve the quality of burn care by clarifying efficacy, safety, and precautions associated with NXB use. These recommendations should be updated as further clinical experience accumulates.

Indexed as

burn escharearly removalenzymatic debridementpurified product of pineapple stem juice extractstatement

Identifiers

PMID42201106
PMCPMC13214741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.