ArticleInfectious disease reports2026
Chromosomal Mechanisms of Colistin Resistance in Clinical Isolates of Carbapenem-Resistant
Article in Infectious disease reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesCarbapenem-resistant
methodsBetween 2010 and 2015, 317 non-duplicate CRKP isolates were collected at Charles Nicolle Hospital, Tunis. Colistin MICs were determined by broth microdilution. Phenotypic tests and PCR characterized carbapenemases, extended-spectrum β-lactamases, AmpC, plasmid-mediated quinolone resistance,
resultsFive isolates (1.6%) were colistin-resistant. All were multidrug-resistant, produced OXA-48, and two also carried NDM-1. The isolates belonged to five distinct sequence types, including high-risk clones (ST11, ST101, ST147). No
conclusionsIn Tunisian CRKP, colistin resistance was associated with chromosomal alterations, predominantly involving disruption of the MgrB-PhoPQ pathway, in the absence of
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