ArticleMedical sciences (Basel, Switzerland)2026
Evaluation of Sarcopenic Obesity in Patients with MASLD.
Niki G Mourelatou, Triada Bali, Magdalini Adamantou, Lampros Chrysavgis, Christos Chologkitas, Margarita Sarri, Dimitra Pavlopoulou, Georgios Schinas, Theodoros Androutsakos, Georgia Sypsa and 5 more
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In one paragraphArticle in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
15 authors.
Niki G MourelatouFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.
Triada BaliFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.
Magdalini AdamantouFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.ORCID 0009-0000-3306-050X Lampros ChrysavgisFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.ORCID 0000-0003-2632-0742 Christos ChologkitasFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.
Margarita SarriFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.
Dimitra PavlopoulouFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.
Georgios SchinasFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.ORCID 0000-0001-7963-1865 Theodoros AndroutsakosDepartment of Pathophysiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece.ORCID 0000-0003-2556-6230 Georgia SypsaDepartment of Radiology, General Hospital of Athens "Laiko", 11527 Athens, Greece.
Dimitrios S KaragiannakisFourth Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Attiko Academic Hospital, 12462 Athens, Greece.ORCID 0000-0003-0082-634X George PapatheodoridisFirst Department of Gastroenterology, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.ORCID 0000-0002-3518-4060 Nikolaos TentolourisFirst Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.ORCID 0000-0003-0615-2534 Anastasia N MavrogiannakiSecond Department of Internal Medicine and Diabetes Centre, NIMTS Hospital, 11521 Athens, Greece.
Evangelos CholongitasFirst Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, General Hospital of Athens "Laiko", 11527 Athens, Greece.ORCID 0000-0002-3645-582X Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Background/Obejctives: Sarcopenic obesity (SO) has gained growing attention in metabolic dysfunction-associated steatotic liver disease (MASLD), yet data in Caucasian populations remain limited. The aim of this study was to assess the prevalence of SO using different definitions and to explore its relationship with steroid androgens, physical performance and frailty in MASLD individuals.
methodsTwo hundred Caucasian patients with MASLD and available dual-energy X-ray absorptiometry (DEXA) data were evaluated. Clinical, biochemical, hormonal and elastography data were recorded, while physical performance was assessed using the Short Physical Performance Battery (SPPB) and Liver Frailty Index (LFI).
resultsSO prevalence ranged from 34.5% to 76.5% depending on the definition applied (AIMSO score, body mass index, and body fat percentage-based criteria). Across definitions, SO individuals showed greater hepatic steatosis, more metabolic comorbidities and demonstrated poorer physical performance. Lower dehydroepiandrosterone sulfate (DHEAS) levels were independently associated with SO when the definition is based on total body fat percentage, and waist circumference (WC) was consistently linked to SO across all definitions. Separate analysis based on gender, confirmed that DHEAS was independently associated with SO in men, while WC represented an independent factor associated with SO in both genders.
conclusionsIn conclusion, SO is common among Caucasian MASLD patients and is accompanied by metabolic, hepatic, hormonal, and functional alterations. These findings may help recognize patients at risk of SO and support more focused assessment and monitoring in clinical practice.
Indexed as
Fatty LiverObesitySarcopeniaAbsorptiometry, PhotonAgedBody Mass IndexDehydroepiandrosterone SulfateFemaleHumansMaleMiddle AgedPrevalenceDehydroepiandrosterone Sulfatedehydroepiandrosterone sulfate (DHEAS)dual-energy X-ray absorptiometry (DEXA)frailtyhormonesliver frailty index (LFI)MASLDphysical performancesarcopeniasarcopenic obesityshort physical performance battery (SPPB)
Identifiers
PMID42201049
PMCPMC13214746
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