Evidence map›Paper›PMID 42201047›Full record

Observational studyMedical sciences (Basel, Switzerland)2026

ICU Admission and Post-Discharge Mortality in COVID-19: Different Risk Factors Across Clinical Phases.

Fernanda Leite, André Santos Silva, Sara Ferreira, Carina Brito, Ângela Leite

Abstract readObservational Study
In one paragraph

Observational study in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fernanda LeiteDepartment of Transfusion Medicine, Santo António University Hospital Center, 4099-001 Porto, Portugal.
André Santos SilvaDepartment of Infectious Diseases, Santo António University Hospital Center, 4099-001 Porto, Portugal.
Sara FerreiraDepartment of Transfusion Medicine, Santo António University Hospital Center, 4099-001 Porto, Portugal.
Carina BritoDepartment of Transfusion Medicine, Santo António University Hospital Center, 4099-001 Porto, Portugal.ORCID 0009-0000-4669-1845
Ângela LeiteCentro de Estudos Filosóficos e Humanísticos, Universidade Católica Portuguesa, 4710-297 Braga, Portugal.ORCID 0000-0003-0560-1756

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRisk factors for severe COVID-19 and in-hospital mortality are well described, but it remains unclear whether the same factors predict mortality after hospital discharge. Distinguishing risk profiles across clinical phases may improve patient management and follow-up strategies.

methodsWe conducted a retrospective observational cohort study of 595 adults hospitalized with PCR-confirmed SARS-CoV-2 infection in Portugal (September-November 2020). The primary outcome was all-cause mortality during hospitalization and up to 120 days post-discharge. Secondary outcomes included intensive care unit (ICU) admission, maximum disease severity (WHO Clinical Progression Scale), oxygen supplementation, and length of stay. Univariable and multivariable regression analyses were performed using logistic regression for binary outcomes and linear regression for continuous outcomes.

resultsOverall mortality was 22.5%, rising from 14.1% in-hospital to 22.5% at 120-day follow-up (

conclusionsRisk factors for acute COVID-19 severity differ from those for post-discharge mortality. These findings support a phase-specific approach to risk stratification, suggesting that patients with obesity are at increased risk of early respiratory deterioration, while patients with malignancy may benefit from closer post-discharge follow-up regardless of ICU admission status.

Indexed as

COVID-19Intensive Care UnitsPatient DischargeAgedFemaleHospitalizationHospital MortalityHumansLength of StayMaleMiddle AgedObesityPortugalRetrospective StudiesRisk FactorsSARS-CoV-2COVID-19disease progressionfollow-up studieshospital mortalityintensive care unitsneoplasmsobesityoxygen inhalation therapypatient dischargerisk factors

Identifiers

PMID42201047
PMCPMC13214800

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.