ReviewMedical sciences (Basel, Switzerland)2026
Imaging of Embryonic and Fetal Brain Development Using MRI Microscopy: Achieving High Spatial Resolution.
Review in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
The visualization of embryonic and fetal brain development at mesoscopic resolution represents a critical frontier in developmental neuroscience. This review presents advances in high-field magnetic resonance imaging (HF-MRI) that achieve unprecedented spatial resolution in ex vivo human embryonic and fetal brain specimens. This mesoscopic imaging capability bridges the gap between conventional clinical MRI and histological microscopy, enabling three-dimensional visualization of transient developmental structures including cortical lamination, ganglionic eminences, and emerging white matter pathways. We review the technical foundations of HF-MRI, present methodological advances that enable mesoscopic resolution, demonstrate applications across gestation, and discuss validation through histological correlation. The integration of multimodal imaging approaches-including T1-weighted, T2-weighted, T2*-weighted, diffusion tensor imaging, and quantitative relaxometry-provides comprehensive characterization of tissue microstructure and connectivity during critical periods of neurodevelopment. These advances offer transformative potential for understanding normal brain development, identifying early markers of neurodevelopmental disorders, and establishing high-resolution atlases of human prenatal neuroanatomy.
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