ArticleMedical sciences (Basel, Switzerland)2026
Outcomes and Predictors of In-Hospital Mortality After Isolated Coronary Artery Bypass Grafting in Patients with Severe Ischemic Cardiomyopathy: A Single-Centre Retrospective Analysis.
Article in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPatients with coronary artery disease (CAD) and severely reduced left ventricular ejection fraction (LVEF) ≤ 30% represent a high-risk group for coronary artery bypass grafting (CABG). Outcomes are of significant concern; therefore, real-world outcome data and predictors of early mortality remain important for perioperative decision-making.
aimThis study aims to evaluate early and mid-term outcomes in patients with severe ischemic cardiomyopathy (LVEF ≤ 30%) undergoing isolated CABG and to identify independent predictors of in-hospital mortality.
methodsWe conducted a retrospective single-centre cohort analysis including patients with preoperative LVEF ≤ 30% undergoing isolated CABG (2017-2021). Early outcomes included in-hospital and 30-day mortality. The mid-term outcome was all-cause mortality up to 36 months. Multivariable logistic regression was used to identify independent predictors of in-hospital mortality. A predefined subgroup comparison was performed for LVEF ≤ 20% versus LVEF 20-30%.
resultsThe study comprised 147 patients with LVEF ≤ 30% undergoing isolated CABG. Overall, in-hospital mortality was 21.1%, and 30-day mortality was 23.8%. Cumulative all-cause mortality was 31.3%, 37.4%, and 42.9% at 12, 24 and 36 months respectively. Patients with LVEF ≤ 20% showed significantly higher early mortality (in-hospital 37.2% vs. 14.4%; 30-day 41.9% vs. 16.3%) and 36-month mortality (58.1% vs. 36.5%) compared with those with LVEF at 20-30%. Independent predictors of in-hospital mortality included preoperative hemodynamic instability, elevated operative risk scores, emergency status, prolonged cardiopulmonary bypass time, and major postoperative complications (all
conclusionsCABG in patients with LVEF ≤ 30% is associated with substantial early mortality, while mid-term survival remains acceptable. Severely reduced LVEF identifies a particularly high-risk subgroup requiring careful perioperative risk stratification.
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