Calcium Channel Blockers in Critical Care Medicine: Current Clinical Applications and Future Investigational Perspectives.

Akram M Eraky, Yasser Mokhtar, Guy Grabau, Adnan Khan, Ashish Acharya, Nichole Gadd, Mark Jarosz, Abhishek Premkumar

Abstract readReview

In one paragraph

Review in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Pharmacokinetic Variability of Direct Oral Anticoagulants and Calcium Channel Blockers: A Comparative Analysis of Exposure Data from Clinical Studies.Pharmaceutics · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akram M ErakyEmergency Medicine Department, Freeman Health System, Joplin, MO 64804, USA.ORCID 0000-0003-4219-3659

Yasser MokhtarPulmonology and Critical Care Medicine Department, Freeman Health System, Joplin, MO 64804, USA.

Guy GrabauPulmonology and Critical Care Medicine Department, Freeman Health System, Joplin, MO 64804, USA.

Adnan KhanPulmonology and Critical Care Medicine Department, Freeman Health System, Joplin, MO 64804, USA.

Ashish AcharyaPulmonology and Critical Care Medicine Department, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Nichole GaddEmergency Medicine Department, Freeman Health System, Joplin, MO 64804, USA.

Mark JaroszInternal Medicine Department, Freeman Health System, Joplin, MO 64804, USA.

Abhishek PremkumarInternal Medicine Department, Freeman Health System, Joplin, MO 64804, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium channel blockers (CCBs) are frequently used in the emergency department and intensive care unit for a wide range of critical conditions, including atrial fibrillation, hypertensive emergencies, acute pulmonary edema with sympathetic crashing, pulmonary hypertension, and vasospastic syndromes. However, their toxicity can lead to significant hemodynamic compromise, underscoring the importance of understanding their pharmacologic effects and safety profile. This review summarizes the current applications of CCBs in critically ill patients, evaluates their safety in congestive heart failure, and highlights emerging therapeutic roles and recent advances in the management of CCB toxicity.

Indexed as

Calcium Channel BlockersCritical CareAtrial FibrillationCritical IllnessHeart FailureHumansHypertension, PulmonaryCalcium Channel Blockersatrial fibrillationcalcium channel blockersCHFhypertensive emergencieshypertensive emergencypulmonary hypertensionvasospasm

Identifiers

PMID42201005

DOI10.3390/medsci14020213

PMCPMC13214944

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.