Evidence map›Paper›PMID 42200818›Full record

ReviewPathophysiology : the official journal of the International Society for Pathophysiology2026

Is There a Unified Etiology of Hypoplastic Left Heart Syndrome? Evaluating Genetic, Structural, and Hemodynamic Models of Disease Initiation.

Reese Leonhard, Zachary Beau Phillips, Jamie Wilson, Zaid Abu-Mowis, John DiGiorgi, Epiphany N Wilson, Zane Borenstein, Laura Wilson, Richard Tang, Elizabeth H Stephens and 6 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pathophysiology : the official journal of the International Society for Pathophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Reese LeonhardCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
Zachary Beau PhillipsCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
Jamie WilsonCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
Zaid Abu-MowisCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
John DiGiorgiCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
Epiphany N WilsonCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
Zane BorensteinCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.ORCID 0009-0000-0923-1284
Laura WilsonCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
Richard TangPediatric Cardiac Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.ORCID 0000-0002-5490-3227
Elizabeth H StephensDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, MN 55905, USA.
Adrian CruceanDepartment of Paediatric Cardiac Surgery, Birmingham Women's and Children's Hospital, Birmingham B4 6N4, UK.
Michael S ShillingfordCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
Giles J PeekCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.ORCID 0000-0002-1313-6498
Mark Steven BleiweisCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.
J Steven AlexanderLouisiana State University Health Sciences Center at Shreveport, School of Medicine, 1501 Kings Highway, Shreveport, LA 71103, USA.ORCID 0000-0001-6975-3711
Jeffrey Phillip JacobsCongenital Heart Center, Departments of Surgery and Pediatrics, UF Health Shands Hospital, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32608, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiac developmentcardiac progenitor cellscongenital heart diseaseendocardial fibroelastosisfetal cardiologygenetic mutationhemodynamicsHLHShypoplastic left heart syndromemyocardial dysplasiavalvar malformation

Identifiers

PMID42200818
PMCPMC13214730

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.