Evidence map›Paper›PMID 42200662›Full record

Observational studyMicrobiology spectrum2026

Detection of asymptomatic group A

Kirsi Gröndahl-Yli-Hannuksela, Matti Waris, Riikka Österback, Jutta Peltoniemi, Mirva Virolainen, Kari Auranen, Teemu Kallonen, Kaisu Rantakokko-Jalava, Jaana Vuopio, Ville Peltola and 1 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kirsi Gröndahl-Yli-HannukselaInstitute of Biomedicine, University of Turku, Turku, Finland.ORCID 0000-0003-1479-8925
Matti WarisInstitute of Biomedicine, University of Turku, Turku, Finland.
Riikka ÖsterbackInstitute of Biomedicine, University of Turku, Turku, Finland.
Jutta PeltoniemiWellbeing Services County of Southwest Finland, Turku, Finland.
Mirva VirolainenInstitute of Biomedicine, University of Turku, Turku, Finland.
Kari AuranenDepartment of Mathematics and Statistics, University of Turku, Turku, Finland.
Teemu KallonenClinical Microbiology, Turku University Hospital, Turku, Finland.
Kaisu Rantakokko-JalavaClinical Microbiology, Turku University Hospital, Turku, Finland.
Jaana VuopioInstitute of Biomedicine, University of Turku, Turku, Finland.
Ville PeltolaDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Lauri IvaskaDepartment of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.ORCID 0000-0001-8935-5032

Funding

Academy of Finland 308482Governmental Research FundingLastentautien TutkimussäätiöPäivikki ja Sakari Sohlbergin SäätiöSuomen Lääketieteen SäätiöThe Outpatient Research Foundation
6 · The paper itself

Abstract

This study aimed to characterize the frequency of asymptomatic group A IMPORTANCE: Group A Streptococcus (GAS) is an increasingly important respiratory pathogen, causing illnesses ranging from life-threatening infections to pharyngitis and asymptomatic carriage. The factors influencing GAS transmission remain poorly defined, and, in the absence of a GAS vaccine, identifying determinants that may guide outbreak-control strategies is essential. In this observational cross-sectional study, substantial asymptomatic carriage was observed among children and adults in daycare centers experiencing GAS outbreaks: 22% by throat culture and 41% by nucleic acid amplification testing (NAAT). Co-detection of respiratory viruses was also common, and in one outbreak, enterovirus detection was more frequent among GAS-positive individuals. These findings provide preliminary insight into the complex dynamics of GAS transmission and highlight asymptomatic carriage and viral co-infections as potential intervention targets. However, the increased sensitivity of GAS NAATs compared with culture may complicate outbreak management by potentially driving unnecessary antimicrobial use.

Indexed as

Carrier StatePharyngitisPharynxStreptococcal InfectionsStreptococcus pyogenesAdolescentAdultChildChild Day Care CentersChild, PreschoolCross-Sectional StudiesDisease OutbreaksFemaleHumansMaleWhole Genome Sequencingenterovirusgroup A Streptococcusnaat diagnosticsoutbreakpharyngitistransmission

Identifiers

PMID42200662
PMCPMC13339969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.