ArticleAngewandte Chemie (International ed. in English)2026
Comment on "Can Charge Transfer Across C─H···O Hydrogen Bonds Stabilize Oil Droplets in Water?"
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reply to the Correspondence on "Can Charge Transfer Across C-H···O Hydrogen Bonds Stabilize Oil Droplets in Water?"Angewandte Chemie (International ed. in English) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Kinetically stable oil nanodroplets in water display an electrophoretic mobility linked to a negative surface charge. The source of this charge is proposed to arise from the adsorption of hydroxide ions or through charge transfer (CT), that is displacement of electronic charge across improper C─H···O hydrogen bonds. Zhao et al. [R. Q. Zhao, H. Y. Shen, R. A. Lacour, J. P. Heindel, M. Head- Gordon, and T. Head-Gordon, Angewandte Chemie- International Edition 64 (2025): e202508145, https://doi.org/10.1002/anie.202508145.] questioned the possibility of CT across an oil droplet interface based on density functional theory simulations of hexane molecules in water. Here, we introduce the two prevalent explanations for the surface charge on oil droplets in water, hydroxide adsorption and CT through improper H-bonds, showing that, while the hydroxide hypothesis is most intuitive, there is no molecular level experimental evidence from a range of surface specific techniques. We correct a misconception about the origin of the blue shift in the original sum frequency scattering work [S. Pullanchery, S. Kulik, B. Rehl, A. Hassanali, and S. Roke, Science 374 (2021): 13661370, https://doi.org/10.1126/science.abj3007.], and comment on the choice of hexane clusters in water: Hexane does not form kinetically stable droplets in water, as it is 9 orders of magnitude more soluble in water than hexadecane. Without exhibiting kinetic stability-the behavior the simulations seek to explain-there is limited predictive ability on CT through improper H-bonds as a mechanism to stabilize droplets.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.