Evidence map›Paper›PMID 42200415›Full record

ArticleJournal of the American Chemical Society2026

Structural and Spectroscopic Basis for Catalysis by a Class C Radical

Bo Wang, Hayley L Knox, Nicholas J York, Matthew I Radle, Alexey Silakov, Squire J Booker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Bo WangDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Hayley L KnoxDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Nicholas J YorkDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Matthew I RadleDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Alexey SilakovDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Squire J BookerDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-7211-5937

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
High-Speed High-Sensitivity Detector for X-ray Micro-Crystallography at GM/CA@APSS10OD012289 · OD · UNIVERSITY OF CHICAGO · PI FISCHETTI, ROBERT F. · 2014 to 2014
$2.0M
NIGMS NIH HHS P30 GM124169NIH HHS S10 OD012289
6 · The paper itself

Abstract

Nosiheptide (NOS) is a ribosomally synthesized and post-translationally modified peptide natural product that exhibits potent antibiotic activity against multiple bacterial pathogens. NOS features a core macrocyclic peptide containing thiazoles, dehydrated serine and threonine residues, and a 3-hydroxypyridine ring. In addition to the macrocycle, NOS possesses a side-ring system formed by a 3-methyl-2-indolic acid (MIA) bridge that connects to glutamyl and cysteinyl residues on the core peptide via ester and thioester linkages. This unique side-ring is installed by the class C radical

Indexed as

MethyltransferasesS-AdenosylmethionineThiazolesBiocatalysisCrystallography, X-RayFree RadicalsModels, MolecularFree RadicalsMethyltransferasesnosiheptideS-AdenosylmethionineThiazoles

Identifiers

PMID42200415
PMCPMC13266988

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.