Evidence map›Paper›PMID 42200403›Full record

ReviewPediatric transplantation2026

Holding On or Letting Go: Immunosuppression After Pediatric Kidney Allograft Failure.

Nicole Hayde, Nancy Rodig, Saritha Ranabothu, Olga Charnaya

Abstract readReview
In one paragraph

Review in Pediatric transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicole HaydeChildren's Hospital at Montefiore, Bronx, New York, USA.ORCID 0000-0003-0519-7271
Nancy RodigBoston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-1471-7710
Saritha RanabothuArkansas Children's Hospital, University of Arkansas Medical Sciences, Little Rock, Arkansas, USA.ORCID 0000-0002-6696-6743
Olga CharnayaJohns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-1104-2882

Funding

Implementation of Eplet Mismatch Analysis in Pediatric Kidney TransplantationK08DK134762 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI Olga Charnaya · 2023 to 2026
$697k
NIDDK NIH HHS K08 DK134762NIH HHS K08DK134762
6 · The paper itself

Abstract

Kidney allograft failure is a devastating event often marked by return to dialysis and is associated with increased morbidity and mortality. Given the young age at transplant for pediatric recipients, they are likely to require retransplantation during their lifetime. Optimal immunosuppression (IS) management in the setting of a failing allograft is crucial to preserve residual renal function, prevent graft intolerance, and limit the development of anti-HLA antibodies. The management of IS during allograft failure is highly variable between providers and reflects the paucity of data to guide clinical decision-making. In addition, pediatric recipients have shorter waiting times for kidney transplants due to priority allocation for deceased donors compared to adult candidates, suggesting that current protocols may not be generalizable to pediatric kidney recipients with allograft failure. In this review we summarize the extent of current recommendations, identify limitations as they pertain to pediatric patients, and provide recommendations for vitally needed future research.

Indexed as

Graft RejectionImmunosuppression TherapyImmunosuppressive AgentsKidney TransplantationAllograftsChildHumansImmunosuppressive Agents

Identifiers

PMID42200403
PMCPMC13266897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.