Evidence map›Paper›PMID 42200309›Full record

ArticleGlia2026

Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro-Inflammatory Responses via Modulation of JNK and NFkB Signaling.

Ronak Patel, Rong Cheng, Christopher L Cardona, Ellen Angeles, Gunjandeep Singh, Sabrina Miller, Archana Ashok, Andrew F Teich, Angel Piriz, Aleyda Maldonado and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Glia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ronak PatelTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.
Rong ChengDepartment of Neurology, CUIMC, New York, New York, USA.
Christopher L CardonaDepartment of Pathology and Cell Biology, CUIMC, New York, New York, USA.ORCID 0000-0001-7463-4565
Ellen AngelesTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.
Gunjandeep SinghTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.
Sabrina MillerTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.
Archana AshokTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.
Andrew F TeichTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.
Angel PirizTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.
Aleyda MaldonadoDepartment of Internal Medicine, Geriatric Division, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, USA.
Ivonne Z Jiménez-VelázquezDepartment of Internal Medicine, Geriatric Division, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, USA.
Richard MayeuxTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.
Joseph H LeeTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.ORCID 0000-0002-2000-4821
Andrew A SproulTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center (CUIMC), New York, New York, USA.ORCID 0000-0001-6972-1592

Funding

The National Institute on Aging (NIA) Late Onset of Alzheimer's Disease (LOAD) Family-Based Study (FBS)U24AG056270 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Gary Wayne Beecham, TATIANA M. FOROUD · 2017 to 2026
$31.4M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1M
Genetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious OrderR01AG067501 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, MILLER, GARY W · 2020 to 2024
$11.7M
Protective genetic factors of Alzheimer disease in PSEN1 Mutation Carriers in Puerto RicoR01AG058918 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEE, JOSEPH HYUNGWOO · 2018 to 2022
$4.3M
Genetic Modifiers of Alzheimer Disease in PSEN1 Mutation Carriers in Puerto RicoR56AG051876 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LEE, JOSEPH HYUNGWOO, MAYEUX, RICHARD P · 2016 to 2016
$842k
BrightFocus Foundation A2015633SHenry and Marilyn Taub FoundationNIA NIH HHS 1P30AG066462-01NIA NIH HHS P30 AG066462NIA NIH HHS R01 AG058918NIA NIH HHS R01AG058918NIA NIH HHS R01 AG067501NIA NIH HHS R01AG067501NIA NIH HHS R56 AG051876NIA NIH HHS U24 AG056270NIA NIH HHS U24AG056270The Thompson Family Foundation TAME-AD
6 · The paper itself

Abstract

Understanding how high-risk individuals are protected from Alzheimer's disease (AD) may illuminate potential therapeutic targets. We identified protective genetic variants in SH3RF3/POSH2 that delayed the onset of AD among individuals carrying the PSEN1

Indexed as

Alzheimer DiseaseMicrogliaNF-kappa BAmyloid beta-PeptidesAnimalsCells, CulturedHumansInflammationNeuronsPresenilin-1Signal TransductionAmyloid beta-PeptidesNF-kappa BPresenilin-1PSEN1 protein, humanAlzheimer's diseaseAβinflammationJNKmicrogliaNFκBPOSH2PSEN1SH3RF3

Identifiers

PMID42200309
PMCPMC13557802

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.