ArticleFrontiers in genetics2026
Comprehensive genomic profiling of neuroendocrine neoplasms of the colorectum.
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neuroendocrine tumors (NETs) are classified into G1, G2, and G3, corresponding to low-grade, intermediate-grade, and high-grade tumors, higher grades show greater aggressiveness and poorer outcomes, with molecular mechanisms remaining unclear. This study aimed to investigate gene mutations across G1, G2, and G3 in 24 colorectal neuroendocrine tumors (CRNETs) using whole-exome sequencing to identify somatic single nucleotide polymorphisms (SNPs). The results showed a prominent T>C single nucleotide variant (SNV) in G1 samples, while C>T was prevalent in G2 and G3. The analysis of significant mutated genes revealed that
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