ArticleFrontiers in medicine2026
Lower preoperative vitamin D levels are associated with poor clinical outcomes in elderly patients with osteoporotic vertebral compression fractures after percutaneous vertebroplasty.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Vitamin D deficiency is common among elderly individuals with osteoporosis; however, its prognostic significance in patients undergoing percutaneous vertebroplasty (PVP) for osteoporotic vertebral compression fractures (OVCFs) remains unclear. This study evaluated the association between preoperative vitamin D status and postoperative pain and functional recovery following PVP. Methods: This retrospective study included 609 elderly patients with single-level OVCFs treated with PVP between January 2021 and December 2024. Preoperative serum 25-hydroxyvitamin D [25(OH)D] levels were categorized as severe deficiency (<10 ng/mL), deficiency (10-20 ng/mL), insufficiency (20-30 ng/mL), and sufficiency (>30 ng/mL). Pain and function were assessed using the Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) preoperatively, on postoperative day 1, at 1 month, and at 1 year. Linear mixed-effects models (LMMs) evaluated longitudinal changes, and multivariable regression examined independent associations with 1-year outcomes. Results: Visual Analog Scale and ODI scores improved significantly over time in all groups (both Conclusion: Lower preoperative vitamin D levels are independently associated with worse postoperative pain relief and functional recovery after PVP in elderly patients with OVCFs.
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