ArticleFrontiers in neuroscience2026
Association between gut microbiota and imaging biomarkers in arteriosclerotic cerebral small vessel disease with idiopathic normal pressure hydrocephalus.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
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17 authors.
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Abstract
Objectives: This study aims to characterize the gut microbiota in arteriosclerotic cerebral small vessel disease and idiopathic normal pressure hydrocephalus (aCSVD-iNPH) patients, investigate its correlation with cerebral small vessel disease imaging markers, and develop a diagnostic model based on differential microbial profiles. Methods: This study enrolled 95 subjects. Fresh fecal samples were collected for microbial DNA extraction. Gut microbiota composition was analyzed using 16S rDNA sequencing, and Spearman's correlation analysis was performed to investigate the association between microbial abundance and imaging indicators. Results: An analysis of gut microbiota diversity revealed no statistically significant differences in Conclusion: This study identifies distinct changes in gut microbiota among patients with aCSVD-iNPH and their associations with aCSVD imaging markers, suggesting that certain microbial taxa may serve as potential diagnostic biomarkers to distinguish aCSVD-iNPH from aCSVD, although these preliminary findings require validation in independent cohorts.
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