Evidence map›Paper›PMID 42199964›Full record

ArticleFrontiers in neurology

Association between circulating biomarkers of one-carbon metabolism and glymphatic system function in cognitive decline of Alzheimer's disease.

Yali Chen, Xia Zhou, Kaigui Wang, He Feng, Bo Tian, Yating Tang, Xiaoqun Zhu, Zhongwu Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yali Chen *Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xia Zhou *Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Kaigui WangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
He FengDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Bo TianDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Yating TangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xiaoqun ZhuDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Zhongwu SunDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Dysfunction in both one-carbon metabolism (OCM) and the glymphatic system has been implicated in the pathogenesis of Alzheimer's disease (AD). However, the potential interrelationship remains poorly understood. This study aimed to investigate the association between OCM biomarkers and glymphatic function in AD and explore their combined effects on cognition. Methods: A total of 210 participants were enrolled, including 68 with normal cognition (NC), 75 with mild cognitive impairment due to AD (AD-MCI), and 67 with dementia due to AD (AD-D). Circulating OCM biomarkers were measured, including serum folate, vitamin B12, and homocysteine levels. Glymphatic-related function was evaluated using the diffusion tensor imaging-analysis along the perivascular space (DTI-ALPS) index, and comprehensive neuropsychological assessments were performed. Results: Serum folate levels ( Conclusion: Lower serum folate levels and reduced DTI-ALPS index were associated with poorer cognitive performance in AD. Their co-occurrence was linked to worse cognitive outcomes. These findings suggest a potential association between metabolic status and glymphatic function in AD, which requires confirmation in longitudinal studies.

Indexed as

Alzheimer’s diseasecognitionDTI-ALPSfolateglymphatic functionhomocysteineone-carbon

Identifiers

PMID42199964
PMCPMC13199100

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