ArticleKidney international reports2026
Interferon-Inducible Gene Upregulation Correlates With Successful Viral Clearance in Patients With BK Polyomavirus-Associated Nephropathy.
Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: BK polyomavirus-associated nephropathy (BKPyVAN) remains a challenging complication after kidney transplantation. Although BKPyV-DNAemia is recommended for screening and reducing immunosuppression, reliable predictors of antiviral immune control are needed. The aim of this study was to identify beneficial gene expression patterns, associated with BKPyV-DNAemia clearance, using a commercially available transcriptomic array assay. Methods: We retrospectively analyzed RNA-based gene expression patterns in 30 biopsy samples with BKPyVAN, using the NanoString nCounter system. We assessed the relationship between gene expression patterns and subsequent BKPyV-DNAemia dynamics, including viral clearance rates at 6 and 12 months after BKPyVAN diagnosis, as well as the course of intermediate graft function. Results: Complete BKPyV-DNAemia clearance was observed in 40% of patients (at 6 and 12 months). BKPyV clearance was significantly associated with upregulation of interferon (IFN)- stimulated genes (ISG): Discussion: Significant upregulation of ISGs in kidney allografts with biopsy-proven BKPyVAN was associated with successful clearance of DNAemia. Higher ISG expression correlated with temporarily worsened graft function, which stabilized on longer follow-up. This first exploratory study suggests a potential role for intragraft ISG measurement in monitoring anti-BKPyV immune response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.