ArticleInternational journal of women's health2026
Turning Challenges into Success: Successful Pregnancy in Advanced Maternal Age with Adenomyosis Using Prolonged GnRH Agonist Protocol: A Case Report.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Advanced maternal age (AMA) is a major challenge in reproductive medicine, compounded by coexisting conditions such as adenomyosis and endometriosis, which impair oocyte competence and endometrial receptivity. Prolonged gonadotropin-releasing hormone agonist (GnRHa) protocols have been proposed to improve in vitro fertilization-embryo transfer (IVF-ET) outcomes. We report the case of a 41-year-old Indonesian woman with 13 years of primary infertility, AMA, adenomyosis, endometriosis, and male factor infertility. Following laparoscopic excision of endometriosis, she underwent a prolonged GnRH agonist protocol with depot triptorelin, followed by controlled ovarian stimulation using recombinant FSH and LH. Despite an initially modest response, eight oocytes were retrieved and all fertilized via ICSI. Two good-quality day-3 embryos were transferred fresh, and three blastocysts were cryopreserved. Intensive luteal support with hCG, progesterone, dydrogesterone, and estradiol was administered. Serial β-hCG confirmed early pregnancy, and at the time of reporting, she is 35+6 weeks pregnant with a viable singleton and unremarkable antenatal course. This case demonstrates that prolonged GnRHa protocols may offer favorable outcomes in women with AMA and multiple adverse prognostic factors, including adenomyosis, endometriosis, and male factor infertility. While encouraging, such results require cautious interpretation, and further prospective studies incorporating preimplantation genetic testing and cumulative live birth rate are needed to clarify their broader applicability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.