Camsap3-mediated microtubules maintain transzonal projections essential for soma-germ communication during ovarian follicle maturation in mice.

Akihiro Aikawa, Takao Tsurumaki, Erina Kuranaga, Junya Ito, Mika Toya, Masamitsu Sato

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Akihiro AikawaLaboratory of Cytoskeletal Logistics, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan.

Takao TsurumakiLaboratory of Cytoskeletal Logistics, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan.

Erina KuranagaLaboratory for Histogenetic Dynamics, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.

Junya ItoLaboratory of Animal Reproduction, School of Veterinary Medicine, Azabu University, Sagamihara Kanagawa, Japan.

Mika ToyaLaboratory of Cytoskeletal Logistics, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan.

Masamitsu SatoLaboratory of Cytoskeletal Logistics, Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oocytes are surrounded by layers of maternal somatic granulosa cells (GCs) in ovarian follicles. GCs extend actin-containing transzonal projections (TZPs) to oocytes across the zona pellucida to establish communication. Microtubules have rarely been observed in TZPs, and their significance in TZP organization and follicular maturation remains unknown. Here, using super-resolution microscopy, we visualized microtubules alongside F-actin in most TZPs. Knockout (KO) mice of the microtubule minus-end binding protein Camsap3 (calmodulin-regulated spectrin-associated protein 3) exhibited infertility without ovulation despite normal estrous cycles. Ovaries of

Indexed as

cell biologyreproductive medicine

Identifiers

PMID42199928

DOI10.1016/j.isci.2026.115911

PMCPMC13200047

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