Evidence map›Paper›PMID 42199921›Full record

ArticleNAR molecular medicine2026

Defective plasticity in dermatomyositis patients muscle stem cells is associated with sustained intrinsic inflammatory signaling and disruption of the histone H3.3 chromatin loading pathway.

Wilhelm Bouchereau, Linda Chenane, Michèle Weiss-Gayet, Lola Lessard, Yseult Cardona, Rémi Mounier, Laure Gallay, Yves Allenbach, Olivier Benveniste, Armelle Corpet and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wilhelm BouchereauUniversité Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle, Lyon, 69008, France.
Linda ChenaneCentre de Recherche en Myologie, Sorbonne Université, INSERM U 974, Hôpital Pitié-Salpêtrière, Paris, 75013, France.
Michèle Weiss-GayetUniversité Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle, Lyon, 69008, France.
Lola LessardUniversité Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle, Lyon, 69008, France.ORCID https://orcid.org/0000-0002-3141-0227
Yseult CardonaUniversité Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle, Lyon, 69008, France.ORCID https://orcid.org/0009-0002-1148-5368
Rémi MounierUniversité Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle, Lyon, 69008, France.
Laure GallayUniversité Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle, Lyon, 69008, France.
Yves AllenbachCentre de Recherche en Myologie, Sorbonne Université, INSERM U 974, Hôpital Pitié-Salpêtrière, Paris, 75013, France.ORCID https://orcid.org/0000-0002-3185-7993
Olivier BenvenisteCentre de Recherche en Myologie, Sorbonne Université, INSERM U 974, Hôpital Pitié-Salpêtrière, Paris, 75013, France.
Armelle CorpetUniversité Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle, Lyon, 69008, France.ORCID https://orcid.org/0000-0002-2126-5783
Bénédicte ChazaudUniversité Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle, Lyon, 69008, France.ORCID https://orcid.org/0000-0002-1262-502X
Patrick LomonteUniversité Lyon 1, CNRS UMR 5261, INSERM U 1315, Institute NeuroMyoGene, Pathophysiology and Genetics of Neuron and Muscle, Lyon, 69008, France.ORCID https://orcid.org/0000-0001-9248-648X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle regeneration is driven by muscle stem cells (MuSCs), which proliferate, differentiate, and fuse to reform myofibers and restore muscle function. This myogenesis process is driven both by intrinsic MuSC properties and extrinsic cues. While coordinated inflammatory signals are necessary for healthy regeneration, chronic inflammation participates in various pathologies affecting the skeletal muscle. In the idiopathic inflammatory myopathy dermatomyositis (DM), MuSCs exhibit impaired myogenesis

Identifiers

PMID42199921
PMCPMC13199706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.