SynthesisFrontiers in psychiatry2026
Adverse outcomes for autistic people: an umbrella review of mental health, physical health, social and lifestyle domains.
Synthesis in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Oral Health-Related Quality of Life and Its Determinants in Children and Adolescents with Autism Spectrum Disorder: A Scoping Review.Dentistry journal · 2026Review
- Early trauma and psychotic experiences in autism: a neurodevelopmental framework integrating allostatic overload, symbolisation, and stress reactivity.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Autistic people experience an increased risk of a wide range of adverse outcomes across many domains, impacting all aspects of daily life. While individual reviews have explored specific outcome areas, a comprehensive cross-domain synthesis is lacking. Because the evidence spans diverse outcome types and review designs, a narrative umbrella synthesis is needed to integrate findings across heterogeneous reviews and provide a broader systems-level overview. Methods: This umbrella review identified and synthesised published systematic, meta-analytic, and narrative reviews on the outcomes associated with autism. Five databases were searched from inception to June 2024. Dual screening and multi-reviewer data extraction were conducted, and methodological quality was appraised using established review tools. Findings were aggregated using inductive narrative synthesis, with domain grouping and thematic classification determined by consensus among reviewers. Results: Of 13,841 records identified, 134 reviews met inclusion criteria. Outcomes were grouped into three organisational domains: mental health, physical health, and social and lifestyle. The most consistently reported adverse outcomes included anxiety and mood disorders, suicidality and self-harm, eating and psychotic disorders, sleep problems, epilepsy, gastrointestinal and feeding difficulties, obesity, oral health problems, increased mortality risk, victimisation and bullying, reduced quality of life, loneliness, relationship difficulties, and unemployment. Evidence strength varied across outcomes, but elevated risk patterns were reported across multiple independent reviews. Discussion: Adverse outcomes for autistic people affect multiple areas of life. This umbrella synthesis identifies the principal outcome clusters supported by review-level evidence and highlights research, clinical practice, and service planning priorities. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42023475389.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.