ArticleJournal of ophthalmology2026
Clinical Microbial Contamination of Multidose Brimonidine: A Prospective Comparison of Benzalkonium Chloride and Purite® Preservatives.
Article in Journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical Microbial Contamination of Multidose Brimonidine: A Prospective Comparison of Benzalkonium Chloride and Purite® Preservatives.Journal of ophthalmology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To compare microbial contamination between multidose brimonidine eye drops preserved with benzalkonium chloride (BAK-MDB) and multidose brimonidine eye drops preserved with Purite® (PUR-MDB) using a comparative approach on the same patient under real-life conditions. Materials and Methods: In this prospective study, 40 glaucoma patients used BAK-MDB and PUR-MDB for three weeks each. From each bottle, the cap and first and second drops were cultured on sheep blood and chocolate agar. Paired comparisons were performed using the exact McNemar test. Associations between patient-related factors and contamination were evaluated using Fisher's exact test and exploratory Firth-penalized logistic regression. Results: The contamination rates on the caps were similar between PUR-MDB and BAK-MDB on sheep blood agar (12.5% vs. 12.5%) and chocolate agar (10% vs. 12.5%) (exact McNemar test, all Conclusion: In our study, no statistically significant difference was observed between BAK-MDB and PUR-MDB in terms of microbial contamination in caps, first and second drops. The exploratory association between education level and contamination risk will need to be confirmed in larger, adequately powered prospective studies.
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Registered trials
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