Evidence map›Paper›PMID 42199854›Full record

SynthesisFrontiers in pharmacology2026

Effects of

XiaoLing Zhu, Qiang Zeng, Yuyu Lei, Danping Xu

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Adjunctive Ashwagandha (Nutrients · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

XiaoLing Zhu *Department of Traditional Chinese Medicine, Qinghai University, Xi Ning, China.
Qiang Zeng *Department of Traditional Chinese Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shen Zhen, China.
Yuyu LeiDepartment of Traditional Chinese Medicine, Qinghai University, Xi Ning, China.
Danping XuDepartment of Traditional Chinese Medicine, Qinghai University, Xi Ning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to systematically review and evaluate the effects of Methods: Following PRISMA guidelines, we searched PubMed, Web of Science, Cochrane Library, and Embase from inception to 1 February 2026. Ramdom control trials were included to evaluate the effects of Ashwagandha on cognitive function, musclestrength, testosterone, body weight, and body fat percentage by meta-analysis using Stata 14. A random-effects model was used to calculate standardized mean differences (SMD) with 95% confidence intervals. To assess the heterogeneity, sensitivity analyses and subgroup analyses were conducted. Methodological quality and risk of bias were assessed with RoB 2, evidence certainty for each outcome was evaluated with GRADE system, and botanical reporting was assessed with the ConPhyMP checklist. Results: Twenty studies with 1,249 participants were included. Ashwagandha significantly improved memory (SMD = 0.52; 95% CI: 0.27-0.78; P < 0.001; I Conclusion: Ashwagandha supplementation significantly improved several aspects of cognitive function (including global cognitive, memory, attention and processing speed, executive function, and visuospatial ability), as well as serum testosterone and muscle strength in adults, but did not affect body weight or body fat percentage. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261292996.

Indexed as

ashwagandhacognitive functionmeta-analysisphysical functionWithania somnifera

Identifiers

PMID42199854
PMCPMC13199302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.