ArticlePhysics and imaging in radiation oncology2026
Trade-offs in proton and photon radiotherapy for pituitary adenomas.
Article in Physics and imaging in radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
Background and Purpose: Pituitary Adenomas (PAs) are tumours proximal to sensitive organs of interest (OOIs). These tumours may be well-suited for proton therapy due to the Bragg peak. Few studies have evaluated the potential dose-volume benefits of protons for PAs in the pencil beam scanning era. Materials and Methods: Treatment plans for 15 PA patients were made using intensity modulated proton therapy (IMPT), coplanar- and- non-coplanar photon therapy. Dose distributions to OOIs were compared using the Radiation Oncology Collaborative Comparison Group's (ROCOCO) Performance Scoring System (RPSS), which estimates adverse event (AE) burden. Results: Proton therapy resulted in significantly lower overall estimated AE burden than both photon modalities (median RPSS: 1.09 vs. 1.24; p < 0.005). This reduction was due to significantly lower D Conclusions: These findings indicate that IMPT can significantly reduce AEs to critical brain structures. Although considerations of cost, accessibility, and clinical validation remain, IMPT may offer a meaningful therapeutic advantage.
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