Evidence map›Paper›PMID 42199821›Full record

ArticleJournal of the American College of Emergency Physicians open2026

Long-Term Outcomes of Trauma Patients After Treatment With Prehospital Tranexamic Acid: A Subgroup Analysis From the PATCH-Trauma Trial.

Biswadev Mitra, Sara MacKenzie, Elyssia M Bourke, Rumer Aldous, Abby Grant, Stephen Bernard, Dashiell Gantner, David J Read, Michael C Reade, Tony Trapani and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Emergency Physicians open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Biswadev MitraSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Sara MacKenzieSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Elyssia M BourkeEmergency Department, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Rumer AldousEmergency Department, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Abby GrantEmergency Department, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Stephen BernardSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Dashiell GantnerSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
David J ReadTrauma Service, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Michael C ReadeRoyal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Tony TrapaniSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Paul S MylesDepartment of Anaesthesiology and Perioperative Medicine, Alfred Health, Melbourne, Victoria, Australia.
Peter A CameronSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Russell L GruenSchool of Medicine and Psychology, Australian National University, Canberra, Australian Capital Territory, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The aim of this study was to assess 24-month functional outcomes of patients randomly assigned to prehospital tranexamic acid (TXA) compared with those assigned to placebo. Methods: The PATCH-Trauma trial assessed administration of TXA by prehospital clinicians and demonstrated greater survival at 28 days from injury among patients allocated to receive TXA, but no difference in favorable functional outcomes at 6 months.This was a subgroup analysis of patients enrolled in the PATCH-Trauma trial. The primary outcome measure was the 8-point Glasgow Outcome Scale-Extended (GOS-E) at 24 months after injury, dichotomized to favorable functional outcomes (GOS-E 5-8) and dead or unfavorable functional outcomes (GOS-E 1-4). We also assessed mortality at 24 hours, 28 days, 6 months, and 24 months after injury. Results: There were 584 patients eligible for inclusion, and 516 patients had data on 24-month outcomes available. Baseline characteristics were comparable. At 24 months, a favorable outcome was reported in 167 (64.0%; 95% CI: 57.8-69.8) patients in the TXA group and 149 (58.4%; 95% CI: 52.1-64.5) in the placebo group ( Conclusion: Prehospital treatment and ongoing hospital infusion of TXA did not result in improved survival or statistically significant functional outcomes at 24 months compared to placebo. Consideration of longer-term outcomes after trauma is recommended for evidence to practice decisions.

Indexed as

blood transfusiondeathemergency medicinehemorrhagicshocktranexamic acidwounds and injuries

Identifiers

PMID42199821
PMCPMC13199829

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.