ArticleFrontiers in endocrinology2026
Association between the serum creatine kinase level and all-cause mortality in centenarians: a prospective cohort study in China.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Muscle mass (MM) has a strong correlation with all-cause mortality. However, its assessment is not easily accessible and expensive. Serum creatine kinase (CK) has been proposed as a solution, but its association with mortality remains unclear. This study aimed to investigate the association between the serum CK level and all-causes mortality among centenarians in China. Methods: This prospective cohort study included Chinese centenarians residing in the community between June 2014 and December 2016. All-cause mortality was analyzed according to serum CK level using restricted cubic spline (RCS) analysis, Cox regression analysis, Kaplan-Meier curves, the log-rank test, and subgroup analysis. Results: In total, 949 centenarians were eligible for participation and were followed up for a median of 29.4 months (IQR 14.5, 51.7). During the study period, 92.9% of the study participants died. RCS analysis revealed an inverse J-shaped relationship between the serum CK level and the risk of death. Mortality was 34.3% higher when the serum CK level was in the range of 8-66 U/L (Q1-Q2) than in the range of 66-192 U/L (Q3-Q4) (HR = 1.343 in multivariable analysis; 95%CI: 1.173-1.538; P<0.001). Kaplan-Meier analysis showed a significantly shorter median survival in the low-CK group (Q1-Q2) compared to the high-CK group (Q3-Q4). (26 months vs 36 months; P<0.001, log-rank test). Conclusions: Among community-dwelling centenarians, serum CK level was independently and inversely associated with all-cause mortality in an inverse J-shaped manner and may serve as a practical biomarker for physiological status and survival.
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