Inflammatory biomarkers associated with infection-related type I acute respiratory failure.

Kairui Ren, Jiatong Xu, Ya Wang, Yan Li, Huadong Zhu

Abstract read

In one paragraph

Article in World journal of emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Kairui RenEmergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Critical and Emergency Pharmaceuticals & Medical Devices Innovation Lab, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.

Jiatong XuEmergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Critical and Emergency Pharmaceuticals & Medical Devices Innovation Lab, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.

Ya WangEmergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Critical and Emergency Pharmaceuticals & Medical Devices Innovation Lab, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.

Yan LiEmergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Critical and Emergency Pharmaceuticals & Medical Devices Innovation Lab, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.

Huadong ZhuEmergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Critical and Emergency Pharmaceuticals & Medical Devices Innovation Lab, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute respiratory failure (ARF) is a heterogeneous syndrome in which early differentiation between infection-related and non-infection-related etiologies remains challenging. This study aimed to characterize the inflammatory profile of type I ARF and identify candidate biomarkers associated with the infection-related type I ARF.

methodsIn this prospective observational cohort study, 98 patients with type I ARF and 30 healthy controls were enrolled. The plasma levels of 92 inflammation-related proteins were measured using the Olink Inflammation Panels. Type I ARF-associated biomarkers were first identified by comparing type I ARF patients with healthy controls, followed by the identification of infection-related biomarkers within the type I ARF cohort. False discovery rate correction and random forest-based feature ranking were applied.

resultsCompared with non-infection-related type I ARF (NonInf-ARF), infection-related type I ARF (Inf-ARF) was associated with a higher incidence of acute respiratory distress syndrome (ARDS) and greater use of advanced life-support therapies. A comparison with healthy controls identified 64 significantly dysregulated biomarkers, representing the inflammatory features of type I ARF. Twenty of the 64 type I ARF-associated biomarkers remained significantly different between the Inf-ARF and NonInf-ARF groups (

conclusionNT-3, IL-18R1, IL-18, and CXCL10 were identified as candidate biomarkers associated with the Inf-ARF, which may provide additional information for early etiologic stratification.

Indexed as

Acute respiratory failureInflammatory biomarkersSubphenotypeType I

Identifiers

PMID42199761

DOI10.5847/wjem.j.1920-8642.2026.049

PMCPMC13199136

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