Bitter gourd bioactive peptide alleviates neuronal ferroptosis after spinal cord ischemia-reperfusion injury, combined with emerging cell and animal models.

Qiyang Diao, Ming Nuo, Qimuge Suyila, Yongzhen Nie, Xiulan Su

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Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Qiyang Diao *Department of Anesthesiology, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Inner Mongolia Medical University, Hohhot, China.

Ming Nuo *Department of Anesthesiology, Inner Mongolia Autonomous Region People's Hospital, Hohhot, China.

Qimuge SuyilaClinical Medical Research Center of the Affiliated Hospital, Inner Mongolia Medical University, Hohhot, China.

Yongzhen NieDepartment of Anesthesiology, Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, Inner Mongolia Medical University, Hohhot, China.

Xiulan SuClinical Medical Research Center of Affiliated Hospital, Inner Mongolia Medical University, Inner Mongolia Bioactive Peptide Engineering Laboratory, Hohhot, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Spinal cord ischemia-reperfusion injury (SCIRI) remains a major clinical challenge with few effective treatments. Ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation, plays a key role in SCIRI pathology, and activation of the Nrf2/HO-1 pathway can counteract this process. Bitter gourd bioactive peptide (BGBP) is a natural low-molecular-weight peptide with antioxidant properties, but its effect on SCIRI induced ferroptosis is unknown. This study aimed to determine whether BGBP protects against SCIRI by inhibiting neuronal ferroptosis via the Nrf2/HO-1 pathway, using two emerging cell and animal models. Methods: An Results and conclusion: BGBP significantly improved BV-2 cell viability under CoCl

Indexed as

bitter gourd bioactive peptideferroptosisNrf2/HO-1oxidative stressSCIRI

Identifiers

PMID42199748

DOI10.3389/fnut.2026.1850363

PMCPMC13199010

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