ArticleFrontiers in nutrition2026
The impact of early enteral nutrition on 28-day mortality in septic shock: a cohort study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Enteral nutrition (EN) in septic shock patients is a double-edged sword. The impact of early enteral nutrition (EEN) on mortality in septic shock patients remains uncertain, and whether this association is modified by vasopressor dosage is also unclear. Objective: The study aimed to investigate the association between EEN and 28-day in-hospital mortality in patients with septic shock and to explore whether the association varied across different dosages of vasopressors during the first 24 h. Methods: Data were extracted from the Chinese Database in Intensive Care (CDIC). Adult septic patients who received vasopressors within 24 h of intensive care unit (ICU) admission were eligible for inclusion. The primary exposure was whether patients received early nutrition within the first 24 h after ICU admission (the EEN group). The primary outcome was 28-day mortality. Multivariate Cox regression models were employed to assess the association between the EEN group and 28-day mortality in the overall population and in patients receiving different vasopressor dosing intensity (VDI) levels. VDI was defined as the total vasopressor dose expressed in norepinephrine equivalents (NEEs), calculated as the time-weighted average over the first 24 h. Results: A total of 26,478 patients were screened and, ultimately, 1855 patients met the inclusion criteria. The median Sequential Organ Failure Assessment (SOFA) score was 11 [interquartile range (IQR): 8-14], and the Acute Physiology and Chronic Health Evaluation (APACHE) II score was 20 (IQR: 15-26). The 28-day in-hospital mortality rate was 19.7%. Compared to patients in the EEN group, those in the late enteral nutrition (LEN) group required higher vasopressor doses (8.7 vs. 10.6 ug/min, Conclusion: Early enteral nutrition was not associated with a lower 28-day mortality risk in patients with septic shock, and it only demonstrated a trend in patients receiving low doses of vasopressors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.