Evidence map›Paper›PMID 42199716›Full record

ReviewJournal of multidisciplinary healthcare2026

Best Evidence for the Exercise-Based Management of Lower Limb Lymphedema After Gynecological Cancer: A Systematic Review and Evidence Synthesis.

Chaonan Zhang, Kim Lam Soh, Putri Yubbu, Jian Chen, Lizhi Yang, Yingying Chen, Jing Wu

Abstract readReview
In one paragraph

Review in Journal of multidisciplinary healthcare, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chaonan ZhangNursing Department, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, SGR, Malaysia.
Kim Lam SohNursing Department, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, SGR, Malaysia.
Putri YubbuDepartment of Pediatrics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, SGR, Malaysia.
Jian ChenDepartment of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, SGR, Malaysia.ORCID 0009-0002-1713-4964
Lizhi YangHealth Medical College, Zhejiang DongFang Polytechnic, Wenzhou, Zhejiang, People's Republic of China.
Yingying ChenSchool of Nursing, Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
Jing WuDepartment of Nursing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Lower limb lymphedema after gynecological cancer treatment significantly impairs quality-of-life, increases care needs, and escalates costs. Despite exercise benefits, evidence-based guidance on optimal interventions is lacking. This study addresses this gap by conducting a systematic review and evidence synthesis of current guidelines and high-quality studies. Patients and Methods: A systematic search was conducted based on the hierarchical "6S" evidence model to retrieve high-quality evidence. Searches in PubMed, CINAHL, Embase, Web of Science, Ovid, BMJ Best Practice, UpToDate, Cochrane Library, major guideline repositories, and PEDro identified guidelines, systematic reviews, recommended practices, evidence summaries, clinical decisions, and expert consensuses on exercise therapy (inception to February 2025). Two reviewers independently screened, evaluated, extracted, and synthesized evidence using the JBI system. Results: Seventeen publications were included. Synthesis across nine domains yielded 32 recommendations. Key findings: recommendations related to patients without active infections or lymphatic leakage only; conduct pre-exercise assessments by qualified professionals; recommend combined aerobic and resistance training. Aquatic therapy, low-impact exercises, and moderate-to-vigorous intensity exercise were beneficial/safe with individualized guidance; use appropriate compression garments during exercise; provide tailored supervision to enhance compliance. Evidence levels and grades specified. Conclusion: This review provides a structured synthesis of the best available evidence for exercise management of lower limb lymphedema in gynecological cancer survivors, covering nine critical aspects. Findings offer a practical guide for clinicians designing interventions.

Indexed as

best evidencecancerexercisegynecologylower limb lymphedema

Identifiers

PMID42199716
PMCPMC13199627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.