Evidence map›Paper›PMID 42199706›Full record

ArticleAntimicrobial stewardship & healthcare epidemiology : ASHE2026

Characterization of aerosols generated during suspected aerosol-generating procedures in healthcare settings.

Caroline A O'Neil, Jiayu Li, Meghan A Wallace, Ramesh Raliya, Yang Wang, Anna Leavey, Traci L Bricker, Carey-Ann D Burnham, Adrianus C M Boon, Pratim Biswas and 1 more

Abstract read
In one paragraph

Article in Antimicrobial stewardship & healthcare epidemiology : ASHE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Caroline A O'NeilWashington University In St Louis: Washington University in St Louis, USA.
Jiayu LiUniversity of Miami College of Engineering, USA.ORCID https://orcid.org/0000-0002-6774-4325
Meghan A WallaceWashington University In St Louis: Washington University in St Louis, USA.
Ramesh RaliyaWashington University In St Louis: Washington University in St Louis, USA.
Yang WangUniversity of Miami College of Engineering, USA.ORCID https://orcid.org/0000-0002-0543-0443
Anna LeaveyWashington University In St Louis: Washington University in St Louis, USA.
Traci L BrickerWashington University In St Louis: Washington University in St Louis, USA.
Carey-Ann D BurnhamWashington University In St Louis: Washington University in St Louis, USA.
Adrianus C M BoonWashington University In St Louis: Washington University in St Louis, USA.ORCID https://orcid.org/0000-0002-4700-8224
Pratim BiswasUniversity of Miami College of Engineering, USA.ORCID https://orcid.org/0000-0003-1104-3738
Hilary M BabcockInfectious Disease, Washington University School of Medicine, St Louis, USA.ORCID https://orcid.org/0000-0001-9015-8378

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To measure aerosol generation during various medical procedures that are potentially aerosol generating and determine whether these aerosols contain viral and/or bacterial pathogens that may pose a risk to healthcare personnel. Design: Observational. Setting: Tertiary care academic hospital. Patients: Convenience sample of adult patients undergoing one of the following procedures: extubation, bronchoscopy, mechanical ventilation, noninvasive ventilation, suctioning, nebulized medication administration (NMA), sputum induction, nasopharyngeal swab, or tracheostomy change. Methods: Four aerosol characterization instruments measured aerosol characteristics (particle mass, number, size); average baseline and procedure measurements were compared to identify changes in aerosolized particles associated with each type of procedure. SKC BioSamplers were used for viral and bacterial pathogen recovery. Clinical data were reviewed to examine patient characteristics that might impact pathogen recovery. Results: Among 93 sampled procedures, differences between baseline versus procedure measurements were only notable for NMA and sputum induction. Smaller increases in some particle measurements were observed for the single extubation sample. None of the 248 BioSampler specimens were positive for a respiratory virus, even though for 39 procedures, the patient had a recent clinical specimen that was positive for a respiratory virus. Thirty-two samples (13%) had positive bacterial cultures, all of which represented common skin/environmental contaminants or upper respiratory microbiota. Conclusions: In this study, significant aerosol generation was only observed during NMA and sputum induction. No viral pathogens and minimal bacteria were recovered from these medically generated aerosols. These data suggest that some procedures that are considered "aerosol-generating" may pose little infectious risk to healthcare personnel.

Identifiers

PMID42199706
PMCPMC13199416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.