ArticleRegenerative biomaterials2026
Zonally patterned demineralized bone matrix-meniscus ECM composite scaffold directing region-specific fibrochondrogenic and angiogenic responses.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
The human meniscus is a zonal fibrocartilage characterized by inner-outer gradients in matrix composition and outer vascularity, essential for mechanical function and tissue integration. However, these hierarchical features are rarely reproduced in current meniscal substitutes, limiting durability and biological integration after repair. Here, we developed a triphasic scaffold composed of a demineralized bone matrix (DBM) framework integrated with regional decellularized meniscus extracellular matrix (DMECM) using riboflavin-mediated photo-crosslinking. This strategy enabled spatial localization of zonal DMECM compartments within a robust scaffold. The zonally patterned DBM + DMECM scaffold preserved interconnected porosity and mechanical stability, supported mesenchymal stem cell (MSC) adhesion and guided region-dependent fibrochondrogenic differentiation
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