ArticleInternational journal of nanomedicine2026
Photodynamic/Photothermal Gold Nanoclusters Chitosan Sponge for Hemostasis and MRSA Infected Wound Healing.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Multidrug-resistant (MDR) bacteria, particularly methicillin-resistant Methods: This study fabricated a new chitosan-based sponge, CS-AuNCs/ICG, to combat MDR bacteria and treat skin wounds. In the CS sponge system, ICG can rapidly generate reactive oxygen species (ROS) upon light irradiation, thereby exerting a rapid bactericidal effect; in contrast, the gold nanoclusters (AuNCs) slowly released from the system can achieve a long-lasting bactericidal effect. Results: In vitro, CS-AuNCs/ICG exhibited excellent antibacterial activity against both planktonic MRSA and biofilm. Moreover, this sponge featured not only an efficient hemostatic property but also a high-porosity porous structure ideal for wound exudate absorption. Local remedy of MRSA-infected mice using the CS-AuNCs/ICG sponge combined with light irradiation resulted in prompt bacterial elimination and prolonged bacteriostasis in the skin wounds, which accelerated wound healing without any observed side effects. Discussion: In summary, the CS-AuNCs/ICG sponge possesses both high-efficiency antibacterial activity and sustained bacterial inhibition ability, demonstrating significant application potential in treating wounds infected with drug-resistant bacteria.
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