ArticleInfectious medicine2026
Oxidative stress index as a potent predictor of disease severity and inflammatory burden in hospitalized COVID-19 patients.
Article in Infectious medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: While the acute phase of the COVID-19 pandemic has passed, understanding its pathophysiology remains critical for managing long-term sequelae and future viral threats. Oxidative stress is a proposed key driver of COVID-19 severity, but its relationship with the dynamic inflammatory cascade and its value as a standalone biomarker requires further validation. Methods: Case-control study was conducted to quantify systemic oxidative stress burden in 109 hospitalized COVID-19 patients (56 severe, 53 mild-moderate) and 112 healthy controls. Serum total oxidant status (TOS) and total antioxidant status (TAS) were measured, and the oxidative stress index (OSI) was calculated and correlated to the inflammatory mediators (IL-6, IL-8, IL-10, IP-10, CRP, SAA). Results: COVID-19 patients exhibited a profound redox imbalance, characterized by elevated TOS and OSI, and depleted TAS compared to controls ( Conclusions: The OSI is a robust, integrative biomarker that strongly reflects COVID-19 severity and is closely linked to the hyperinflammatory state. The OSI is strongly correlated with increased inflammatory cytokines and acute-phase proteins in acute COVID-19.
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