ArticleFrontiers in aging neuroscience2026
Decreases in the sustained firing capacity of layer 2/3 pyramidal neurons in the anterior cingulate cortex of aged rats.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anterior cingulate cortex (ACC) is particularly vulnerable to aging, which impairs cognitive functions such as attention and working memory. Although aging is known to alter intrinsic electrophysiological properties in other brain regions, the differences in the properties of aged ACC neurons and young adult neurons remain uninvestigated. In this study, we compared the intrinsic membrane properties and firing characteristics of aged layer 2/3 pyramidal neurons (26-month-old rats) with those of young adult neurons (6-month-old rats) using whole-cell patch-clamp recordings in acute slices from male Long-Evans rats. Although the distribution of the aged neurons based on the firing patterns did not significantly differ from that of the young adult neurons, the aged neurons exhibited depolarized resting membrane potentials, decreased input capacitance, and increased input resistance. In regular-spiking neurons, compared with young adult neurons, aged ACC neurons presented higher action potential thresholds, smaller action potential amplitudes, narrower action potential half-widths, and smaller slow afterhyperpolarization (sAHP) amplitudes. While basic excitability under standard step currents was preserved, aged regular-spiking neurons did not show sustained firing under ramp or triangular current stimulation, with rapid decreases in the firing frequency following the ramp peak and premature spike termination during the triangular descending phase, respectively. These results indicate that the intrinsic membrane properties of aged ACC neurons differ from those of young adult neurons and that aged neurons exhibit a reduced capacity for sustained firing. This cellular dysfunction in aged neurons provides a potential physiological mechanism underlying the age-related decline in ACC-dependent cognitive functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.