ArticleFrontiers in microbiology2026
Comparison of targeted next-generation sequencing and conventional tests for pathogen detection in community-acquired and severe community-acquired pneumonia: a retrospective cohort study.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical characteristics, co-detection patterns and prognostic risk factors of human metapneumovirus infection in children: a retrospective study.Frontiers in cellular and infection microbiology · 2026Article
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7 authors.
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Abstract
Background: Community-acquired pneumonia (CAP) and severe community-acquired pneumonia (sCAP) impose a significant burden on the healthcare system. As a more severe form of CAP, sCAP is associated with a higher mortality rate, and patients frequently require intensive care. Identifying clinical biomarkers to distinguish CAP from sCAP is expected to improve pneumonia management and patient outcomes. Targeted next-generation sequencing (tNGS) has considerable potential for pathogen detection and distinguishing microbial profile differences between CAP and sCAP. Methods: In this retrospective cohort study, we analyzed 380 bronchoalveolar lavage fluid (BALF) samples from patients diagnosed with CAP or sCAP who underwent both conventional tests (CTs) and tNGS to identify and compare the pathogen species and clinical consistency. Results: The results were as follows: tNGS demonstrated a significantly higher clinical consistency rate with the final diagnosis (83.02%) than CTs (38.37%), with a statistically significant difference ( Conclusion: Targeted next-generation sequencing demonstrated superior performance as a sensitive auxiliary diagnostic tool, which resulted in an increased pathogen identification rate and higher clinical diagnostic consistency. Although tNGS provides more comprehensive detection of etiological agents, clinical interpretation, diagnosis, and prediction require careful integration with conventional tests. The distinct clinical features, pathogen profiles, and pathogen composition between patients with CAP and those with sCAP highlight the need for a comprehensive diagnostic approach in pneumonia management.
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