Evidence map›Paper›PMID 42199511›Full record

ArticleBiologics : targets & therapy2026

Long-Term TIE2 Inhibition in a TEK-Mutated Venous Malformation: A 3-Year Clinical Experience.

Paloma Triana, Elena Marín, Covadonga Mendieta, Lucía Fernández, Lara Rodriguez-Laguna, Juan Carlos Lopez-Gutierrez

Abstract readCase Reports
In one paragraph

Article in Biologics : targets & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paloma TrianaPediatric Surgery, La Paz Hospital, Madrid, Spain.ORCID 0000-0002-8176-6010
Elena MarínVascular Surgery, La Paz Hospital, Madrid, Spain.
Covadonga MendietaVascular Surgery, La Paz Hospital, Madrid, Spain.
Lucía FernándezInterventional Radiology, La Paz Hospital, Madrid, Spain.
Lara Rodriguez-LagunaGenetics, La Paz Hospital, Madrid, Spain.
Juan Carlos Lopez-GutierrezPediatric Surgery, La Paz Hospital, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Venous malformations (VMs) are slow-flow vascular anomalies frequently driven by somatic activating mutations in Case Presentation: We report a 51-year-old patient with a diffuse VM involving the right cervical region, thorax, and upper extremity, associated with a somatic mosaic Conclusion: This second long-term clinical experience supports the sustained efficacy and safety of TIE2 inhibition in selected

Indexed as

rebastinibtargeted therapiesTIE2 inhibitorvascular malformationsvenous malformations

Identifiers

PMID42199511
PMCPMC13199604

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.