ReviewFrontiers in pediatrics2026
Reflections on so-called culture-negative osteoarticular infections in pediatric populations.
Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Osteoarticular infections (OAIs) in children persist to be a major clinical concern due to their potential long-term impact on bone growth and joint function. Despite careful sampling, a significant proportion of OAIs remain culture-negative, historically obscuring the true epidemiology of these conditions. At the same time, subacute osteomyelitis is increasingly being detected and recognized as a distinct osteoarticular infection. Subacute hematogenous osteomyelitis (SAHO) is often under-recognized, as it is typically characterized by localized pain, mild or absent systemic manifestations, non-contributory laboratory tests and blood cultures, but positive radiological findings. This review focuses on the phenomenon of so-called culture-negative OAIs, exploring their microbiological basis, the role of fastidious and atypical microorganisms, parallels with subacute osteomyelitis, and the role of modern diagnostic technologies.
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