Evidence map›Paper›PMID 42199429›Full record

ArticleFrontiers in immunology2026

Preparation of a multiepitope vaccine candidate for camel bocavirus and evaluation of its immunogenicity in a mouse model.

Xinyu Tao, Qian Jiang, Yumeng Liang, Xin Li, Xiaojun Ding, Li Yang, Fang Min, Tao Tian, Ruizhen Zhao, Nadiya Duishanbieke and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xinyu Tao *Xinjiang Agricultural University, Urumqi, China.
Qian Jiang *Xinjiang Agricultural University, Urumqi, China.
Yumeng LiangXinjiang Agricultural University, Urumqi, China.
Xin LiXinjiang Agricultural University, Urumqi, China.
Xiaojun DingXinjiang Agricultural University, Urumqi, China.
Li YangXinjiang Agricultural University, Urumqi, China.
Fang MinXinjiang Agricultural University, Urumqi, China.
Tao TianXinjiang Agricultural University, Urumqi, China.
Ruizhen ZhaoXinjiang Agricultural University, Urumqi, China.
Nadiya DuishanbiekeXinjiang Agricultural University, Urumqi, China.
Salamaiti SilajidingXinjiang Agricultural University, Urumqi, China.
Yi ZhangXinjiang Agricultural University, Urumqi, China.
Zhanqiang SuXinjiang Agricultural University, Urumqi, China.
Gang YaoXinjiang Agricultural University, Urumqi, China.
Xuelian MaXinjiang Agricultural University, Urumqi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Dromedary camel bocavirus (DBoV) poses a threat to camel health, yet no vaccine is available. Methods: Using immunoinformatics, B-cell, CTL, and HTL epitopes from VP1/VP2 were predicted. Four multi-epitope constructs (DBoV-A1 to A4) were designed with different adjuvants and evaluated in silico; DBoV-A2 and A4 were expressed, purified, and tested in BALB/c mice. Results: DBoV-A2 and A4 showed strong in silico binding to TLR9 and stable molecular dynamics. In mice, both induced significant IgG, IgM, IgA responses, Th1/Th2 cytokine secretion, and CD4⁺ T cell expansion without organ toxicity. Discussion: The consistency between computational predictions and in vivo immunogenicity supports these constructs as promising DBoV vaccine candidates.

Indexed as

CamelusEpitopesImmunogenicity, VaccineParvoviridae InfectionsViral VaccinesAnimalsAntibodies, ViralCytokinesEpitopes, B-LymphocyteEpitopes, T-LymphocyteFemaleImmunoinformaticsMiceMice, Inbred BALB CProtein Subunit VaccinesAntibodies, ViralCytokinesEpitopesEpitopes, B-LymphocyteEpitopes, T-LymphocyteProtein Subunit VaccinesViral Vaccinescellular immunitydromedary camel bocavirushumoral immunityimmunoinformaticsmulti-epitope vaccine

Identifiers

PMID42199429
PMCPMC13199348

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.