Evidence map›Paper›PMID 42199409›Full record

ArticleFrontiers in immunology2026

Second-order regulation: IFN-γ suppresses IL-17A-mediated type 3 inflammation.

Vijay Raaj Ravi, Sophia H Maxfield, Emma N Niszczak, Hannah Y Kim, Olivia S Harlow, Anjali Kakarla, Kalyn D Whitehead, Anukul T Shenoy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Vijay Raaj Ravi *Dept. of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Sophia H Maxfield *Dept. of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Emma N NiszczakDept. of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Hannah Y KimDept. of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Olivia S HarlowDept. of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Anjali KakarlaDept. of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Kalyn D WhiteheadDept. of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.
Anukul T ShenoyDept. of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, United States.

Funding

RESEARCH TRAINING IN EXPERIMENTAL IMMUNOPATHOLOGYT32AI007413 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Bethany B. Moore · 1993 to 2026
$9.8M
Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
CTSA Predoctoral T32 at the University of MichiganT32TR004371 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI L ELLINGROD, MICHAEL Allan HOLINSTAT · 2023 to 2026
$2.2M
Lung epithelial cell reprogramming by CD4 T cellsR00HL157555 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SHENOY, ANUKUL T · 2023 to 2025
$747k
NCATS NIH HHS T32 TR004371NHLBI NIH HHS R00 HL157555NIAID NIH HHS T32 AI007413NIAID NIH HHS T32 AI007528
6 · The paper itself

Abstract

Background: T helper 1 (T Methods: We devised a simplified reductionistic model to determine the role of IFN-γ in IL-17A-driven inflammation during Results: IFN-γ promptly muted IL-17A-induced inflammatory cell accumulation in Conclusions: Our findings identify a distinct immunoregulatory mechanism that operates within non-lymphoid tissues, where IFN-γ limits IL-17A-mediated type 3 inflammation via STAT1. Thus, the frequent accompaniment of T

Indexed as

InflammationInterferon-gammaInterleukin-17Streptococcus pneumoniaeTh17 CellsAnimalsFemaleLungMaleMiceMice, Inbred C57BLMice, KnockoutSTAT1 Transcription FactorTh1 CellsIl17a protein, mouseInterferon-gammaInterleukin-17Stat1 protein, mouseSTAT1 Transcription FactorCD4+ T cellsIFN-γIL-17lungmucosal immunitySTAT1TH17 cellsTH1 cells

Identifiers

PMID42199409
PMCPMC13199338

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.