Evidence map›Paper›PMID 42199384›Full record

ArticleBioactive materials2026

Nano-to-macroscale dual core-shell structured bioartificial ligament improves outcomes of anterior cruciate ligament reconstruction in rats: A proof-of-concept study.

Haozhi Zhang, Yuanming An, Ying Luo, Lei Lei, Zhenkang Wen, Xin Chen, Linlong Li, Michael Tim-Yun Ong, Lizhen Zheng, Wenxue Tong and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Haozhi ZhangMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Yuanming AnMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Ying LuoSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Guangdong, China.
Lei LeiCentre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation (lnnoHK), Chinese Academy of Sciences, Hong Kong Special Administrative Region of China.
Zhenkang WenMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Xin ChenMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Linlong LiState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Jilin, China.
Michael Tim-Yun OngMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Lizhen ZhengCentre for Regenerative Medicine and Health, Hong Kong Institute of Science and Innovation (lnnoHK), Chinese Academy of Sciences, Hong Kong Special Administrative Region of China.
Wenxue TongMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Yu-Sheng HsuehMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Bingyang DaiMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Shian ZhangMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Bruma Sai-Chuen FuMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Jiali WangSchool of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Guangdong, China.
Jiankun XuMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Patrick Shu-Hang YungMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
Ling QinMusculoskeletal Research Laboratory, Centre for Musculoskeletal Degeneration & Regeneration, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over 400,000 anterior cruciate ligament (ACL) reconstructions are performed worldwide annually. The ability of patients to return to their pre-injury or adapted level remains limited. Although autografts and allografts are recognized as good choices for ACL reconstruction, postoperative complications are frequently reported. The emergence of artificial ligaments offers a promising strategy to solve these challenging medical conditions. However, artificial grafts composed of different materials have been associated with complications such as chronic effusions, synovitis, and graft failure to varying degrees. Although great progress has been made in modifying artificial grafts, the optimal strategy remains to be explored. Magnesium and recombinant spidroin have been proven to be promising implantable materials that can facilitate osteogenesis both

Indexed as

Anterior cruciate ligament reconstructionArtificial ligamentConjugate coaxial electrospinningGraft-bone integrationMagnesium

Identifiers

PMID42199384
PMCPMC13200050

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.