ArticleExploratory research in clinical and social pharmacy2026
Deprescribing of proton pump inhibitors in internal medicine in-patients: A retrospective observational study.
Article in Exploratory research in clinical and social pharmacy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
7 authors.
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Abstract
Background: Proton pump inhibitors (PPI) treat gastrointestinal disorders and are often overprescribed or continued unnecessarily, despite potential long-term adverse effects (e.g. infections). Deprescribing is recommended when indications are unclear or treatment unnecessarily prolonged. In Switzerland, national guidelines on PPI deprescribing are lacking. This study assessed PPI deprescribing frequency, appropriate new prescriptions and possible reasons for not performing deprescribing. Methods: Retrospective study at the Inselspital, Bern, Switzerland. Included were patients ≥18 years admitted to internal medicine wards during January-February 2022 with PPI on admission or newly prescribed during hospitalization. PPI duration and indication were retrieved from electronic health records. Data were evaluated with descriptive statistics and multivariable regression models. Results: Among 852 admissions, 54% ( Conclusion: Most PPI were continued upon discharge, despite half lacking a clearly appropriate use. Knowledge, communication and information gaps may have contributed to missed deprescribing opportunities. Regular medication reviews across healthcare settings could improve deprescribing practices and ensure appropriate PPI use.
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