Evidence map›Paper›PMID 42199360›Full record

ArticleMaterials today. Bio2026

NIR-II-triggered copper single-atom catalyst depots coupling catalysis and drug release for infected chronic wounds with dysregulated inflammation.

Mingqian Wang, Jiamu Xiao, Songjie Han, Wei Lu, Ziyi Li, Xu Dai, XueFeng Jiang, Jiale Zhang, Haomiao Zhu, Donglin Gan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mingqian WangNational and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
Jiamu XiaoNational and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
Songjie HanDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.
Wei LuNational and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
Ziyi LiNational and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
Xu DaiNational and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
XueFeng JiangNational and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
Jiale ZhangDepartment of Joints II, The Third People's Hospital of Dalian, Dalian, 116000, China.
Haomiao ZhuNational and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
Donglin GanNational and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise control of antimicrobial and immunomodulatory signals in both space and time is essential for addressing drug-resistant chronic wounds. Here, an NIR-II-responsive nanomedicine depot is created by integrating fasudil (FAS) into a copper single-atom catalyst scaffold (Cu SACs/FAS), which is formed through a coordination-constrained pyrolysis process. Under 1064-nm irradiation, Cu SACs/FAS couples photothermal heating with dual enzyme-mimicking activities (peroxidase-like catalysis and GSH depletion), producing reactive oxygen species (ROS) and copper-dependent bacterial stress consistent with cuproptosis-related injury. The porous framework enables on-demand, sustained FAS release, which promotes macrophage polarization toward a pro-angiogenic phenotype and mitigates excessive inflammation. The platform achieves broad-spectrum antibacterial activity against

Indexed as

Anti-inflammationBacterial cuproptosisNanomedicine depotNanozymesTissue regeneration

Identifiers

PMID42199360
PMCPMC13199899

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.