Evidence map›Paper›PMID 42199355›Full record

ArticleMaterials today. Bio2026

The coprecipitation-functionalized 3D-printed GM/PDA/PRF hydrogel for infected bone regeneration via synergistic photothermal antibacterial and osteogenic activity.

Zihang Yu, Lei Miao, Shuchang Liu, Lijun Zhang, Xiaoqing Wang, Yujia Han, Ziwen Cao, Fan Liu, Zhongti Zhang, Yulou Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zihang YuDepartment of Orthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.
Lei MiaoDepartment of Periodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.
Shuchang LiuDepartment of Orthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.
Lijun ZhangDepartment of Orthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.
Xiaoqing WangDepartment of Orthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.
Yujia HanDepartment of Orthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.
Ziwen CaoDepartment of Orthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.
Fan LiuDepartment of Orthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.
Zhongti ZhangThe VIP Department, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.
Yulou TianDepartment of Orthodontics, School and Hospital of Stomatology, Liaoning Provincial Key Laboratory of Oral Diseases, China Medical University, No. 117 Nanjing North Street, Shenyang, Liaoning, 110002, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To address insufficient osteogenesis and persistent infection in infected bone defects, we developed a dual-functionalized hydrogel by integrating polydopamine (PDA) and platelet-rich fibrin (PRF) into a 3D-printed gelatin methacryloyl/methylcellulose (GM) matrix. Two functionalization strategies, surface adsorption and coprecipitation, were employed to fabricate GM/PRF-A and GM/PRF-C scaffolds. Comprehensive characterization revealed both scaffolds exhibited favorable hydrophilicity, controllable degradation and improved mechanical properties. The incorporation of PDA within hydrogels displayed NIR-responsive photothermal antibacterial activity, as well as serving as a bio-adhesive to stabilize PRF and enable on-demand growth-factor release. Both functionalization strategies promoted the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. Compared with the adsorption-based scaffold, the coprecipitation-functionalized hydrogel showed more sustained growth-factor release, better antibacterial efficacy, and superior osteogenic performance

Indexed as

3D printingCoprecipitationInfected bone repairPhotothermal antibacterialPolydopamine

Identifiers

PMID42199355
PMCPMC13199900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.