ArticlePlastic and reconstructive surgery. Global open2026
Systematic Review of Comparative Studies Evaluating Hyperbaric Oxygen Therapy on Skin Flap and Graft Surgical Indications.
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: This systematic review aims to determine whether pre- and postoperative hyperbaric oxygen therapy (HBOT) incurs any benefits or harms in soft tissue injuries (STIs) considered for skin flap or graft surgery. Methods: We included adequately powered clinical trials that enrolled patients with STIs serious enough for skin flaps or grafts; evaluated HBOT (≥1.5 ATA) versus control, placebo, or sham procedures; and analyzed survival/healing and complication rates. MEDLINE, Google Scholar, and Embase were searched for relevant literature through June 30, 2024. The Cochrane risk of bias (RoB 2) and the ROBINS-I tools assessed RoB. Meta-analysis and random effects models analyzed randomized controlled trial (RCTs) evaluating flap/graft survival rates within 4 weeks of HBOT (2-2.5 ATA). The GRADE approach determined the evidence recommendations. Results: Among 743 records screened, 45 were assessed; 25 reports from 24 studies (13 RCTs; 11 non-RCTs; 2246 patients) were included. RCT RoB ranged from low RoB (1 trial) to high (2 trials). Nonrandomized trials had moderate RoB (n = 5, 45%), whereas 6 had serious RoB. Four RCTs showed a large, horizontal overall effect size (log odds ratio, 1.045; standard error, 0.3104; Conclusions: A strong recommendation for pre- and postoperative HBOT is warranted to mitigate the need for flap/graft surgery and heal flaps and grafts, given the potentially life- and/or limb-threatening harms that could otherwise occur.
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Registered trials
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