ArticleIranian journal of pathology2026
Differential IDH1 Immunohistochemical Expression Across the Pathologically Stratified Spectrum of Intraepithelial and Invasive Laryngeal Squamous Cell Lesions.
Article in Iranian journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background & Objective: Laryngeal carcinoma is a common head and neck cancer with high morbidity and mortality. This study evaluates IDH1 immunohistochemical expression in pre-invasive and invasive laryngeal squamous cell lesions, its correlation with clinicopathological features, and its prognostic and therapeutic potential. Methods: A retrospective analysis of 65 laryngeal squamous cell lesion cases was conducted using IDH1 immunohistochemistry. Results: IDH1 expression significantly correlated with invasion status (intensity and H-score; p = 0.026, 0.025) and histopathological progression and grade (p = 0.033, 0.036). Two-year DFS and OS were 81.5% and 69%, respectively, with no significant association between survival outcomes and IDH1 H-score (p = 0.851, 0.225). Conclusion: According to our findings, increased IDH1 expression may be associated with features of aggressive tumor behavior and could hold clinical significance in laryngeal squamous cell lesions, potentially serving as a future therapeutic target.
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