Evidence map›Paper›PMID 42199008›Full record

Trial reportGut microbes2026

Increasing plant protein sources in the diet modulates gut microbiota and tryptophan metabolism in men at cardiometabolic risk.

Gaïa Lépine, Anne-Marie Davila, Gwendal Cueff, Gisèle Pickering, Farid Ichou, Caroline Perreau, Catherine Lefranc-Millot, Marine Gilles, Florence Thirion, François Mariotti and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04236518 (Nutritional Transitions to More Plant Proteins and Less Animal Proteins), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04236518 nacompletednot on this map

Nutritional Transitions to More Plant Proteins and Less Animal Proteins: Understanding the Induced Metabolic Reorientations and Searching for Their Biomarkers

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2020 to 2022Enrolled53ConditionsMetabolic Syndrome, Hypertriglyceridemia, Fasting Blood Sugar Above Normal, Lower Than Standard HDL-cholesterol LevelArmsDiets with either predominantly animal protein sources., Diets with predominantly plant protein sources
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gaïa LépineUniversité Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, France.ORCID 0009-0007-7988-1830
Anne-Marie DavilaUniversité Paris-Saclay, AgroParisTech, INRAE, Palaiseau, France.ORCID 0000-0003-4469-5628
Gwendal CueffUniversité Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, France.
Gisèle PickeringPlatform of Clinical Investigation Department, University Hospital Clermont-Ferrand, Inserm CIC, Clermont-Ferrand, France.
Farid IchouFoundation for Innovation in Cardiometabolism and Nutrition (IHU ICAN), ICAN Omics, Paris, France.ORCID 0000-0001-6293-5133
Caroline PerreauRoquette Frères, Lestrem, France.
Catherine Lefranc-MillotRoquette Frères, Lestrem, France.
Marine GillesUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.ORCID 0009-0003-6650-7824
Florence ThirionUniversité Paris-Saclay, INRAE, MGP, Jouy-en-Josas, France.ORCID 0000-0002-2310-5548
François MariottiUniversité Paris-Saclay, AgroParisTech, INRAE, Palaiseau, France.ORCID 0000-0002-4516-3853
Didier RémondUniversité Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, France.ORCID 0000-0003-4430-0067
Hélène FouilletUniversité Paris-Saclay, AgroParisTech, INRAE, Palaiseau, France.ORCID 0000-0003-3932-251X
Sergio PolakofUniversité Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, France.ORCID 0000-0002-0976-8732

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the effect of partially substituting dietary animal with plant protein (PP) sources on the fecal microbiota composition and metabolome in men with increased cardiometabolic risk. In a randomized, controlled, crossover feeding trial (NCT04236518), 19 men with high plasma triglycerides and waist circumference completed two 4-week isoenergetic diets: a flexitarian diet high in PP sources (FLEX, 64% PP) and a more animal-based control diet (CON, 36% PP). Fecal microbiota (shotgun metagenomics: taxa and metabolic pathways) and metabolome (targeted LC-MS) profiles were assessed before and after each diet and integrated with the host plasma metabolome. Delta values (Δ

Indexed as

Gastrointestinal MicrobiomePlant ProteinsTryptophanAdultBacteriaCardiometabolic Risk FactorsCross-Over StudiesDietFecesHumansIndolesMaleMetabolomeMiddle Agedindolepropionic acidIndolesPlant ProteinsTryptophanfibersflexitarian dietsindoleindole propionic acidindoxyl sulfatekynurenic acidlegumesmulti-omicsobesityoverweightPlant-based dietspulses

Identifiers

PMID42199008
PMCPMC13217912

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.