Evidence map›Paper›PMID 42198971›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

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Yuxing Lin, Sinan Shi, Jing Wang, Siyue Lin, Jie Zhang, Shanshan Lin, Yishurong Chen, Ling Zhang, Qiaoyan Cai

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuxing LinCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Sinan ShiCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Jing WangCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Siyue LinCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Jie ZhangCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Shanshan LinCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Yishurong ChenCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Ling ZhangCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Qiaoyan CaiCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.

Funding

National Natural Science Foundation of China 82374282
6 · The paper itself

Abstract

objectivesTo investigate the mechanism by which

methodsEighteen C57BL/6 mice were randomized into control group, angiotensin II (AngII) group, and Ang II+QDG group (

resultsContinuous infusion of Ang II resulted in significant elevation of systolic blood pressure, diastolic blood pressure, and mean arterial pressure in the mice, causing also widening of the perivascular space of the cerebral microvasculature, reduction of CD31 and Bcl-2 expressions, and increases in the expressions of p53, Bax, cleaved caspase-3, and cleaved caspase-9. All these changes were significantly mitigated by treatment with QDG. In bEnd.3 cells, QDG treatment significantly attenuated OGD/R-induced apoptosis, increased Bcl-2 expression, and decreased expressions of P53, Bax, cleaved caspase-3, and cleaved caspase-9.

conclusionsQDG suppress apoptosis of cerebral microvascular endothelial cells in hypertensive rats by downregulating the P53 signaling pathway to alleviate cerebral microvascular endothelial injury caused by hypertension.

Indexed as

ApoptosisDrugs, Chinese HerbalEndothelial CellsHypertensionSignal TransductionTumor Suppressor Protein p53Angiotensin IIAnimalsbcl-2-Associated X ProteinBrainCaspase 3Caspase 9MaleMiceMice, Inbred C57BLMicrovesselsAngiotensin IIBax protein, mousebcl-2-Associated X ProteinBcl2 protein, mouseCasp3 protein, mouseCaspase 3Caspase 9Drugs, Chinese HerbalProto-Oncogene Proteins c-bcl-2qingda granulesTrp53 protein, mouseTumor Suppressor Protein p53apoptosiscerebral microvascular endothelial cellshypertensionP53 signaling pathwayQingda Granules

Identifiers

PMID42198971
PMCPMC13213342

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.